After spending most of her life exploring the jungle with her mother Elena (Eva Longoria) and her father Cole (Michael Peña), Dora (Isabela Moner) could not prepare for the most dangerous adventure of all time – the high school , An excursion to the Natural History Museum seems to be familiar territory for the young explorer, but only until she, Diego (Jeffrey Wahlberg) and two of her friends are abducted by thieves. Dora is supposed to help the crooks find their parents, as they are looking for Parapata, an old lost city. The city would be a significant archaeological find and the bandits want to enrich it. So everyone is brought to Peru. Shortly after arrival, the friends of Alejandro Gutierrez (Eugenio Derbez), a mysterious inhabitant of the jungle, are rescued. From now on, Dora and her companions take a hike to the unknown to save their parents and solve the mysterious mystery behind the lost Inca civilization.