After murdering family patriarch and crime writer Harlan Thrombey (Christopher Plummer) on his 85th birthday, his birthday party turns into a mystery dinner. The relatives present, of course, do not want to hear anything, but they are still being held by the detectives Benoit Blanc (Daniel Craig) and Lieutenant Elliott (Lakeith Stanfield) until the culprit is found. This does not suit the guests like Ransom Drysdale (Chris Evans) and his parents Linda (Jamie Lee Curtis) and Richard Drysdale (Don Johnson) at all. Although Thrombey’s party society is anything but cooperative, it comes in the course of the evening to some surprising twists and the situation is getting worse. The investigating officers must fight their way through a tangled web of intrigue, lies, and false tracks to clear up the mysterious death.