Wichita (Emma Stone), Little Rock (Abigail Breslin), Columbus (Jesse Eisenberg) and Tallahassee (Woody Harrelson) are back and continue on their way through a world that is fallow after a zombie apocalypse. This also has its advantages, but you can now make yourself comfortable in the orphaned White House, after having freed this from stray undead. But the colorful troupe is also faced with challenges: When Little Rock and Wichita run through together, Columbus and Tallahassee have to deal with two at a time. But shortly after Columbus met the pretty, but not very smart Madison (Zoey Deutch), Wichita returns at once: Little Rock has run away with the stoner Berkeley (Avan Jogia) and Wichita needs help in the search. The four not only meet zombies that have evolved, but also other survivors. Above all, they have to face the growing problems of their own, motley, forced family.